Reese Witherspoon
Susan Murphy / Ginormica (voice)
A woman transformed into a giant after she is struck by a meteorite on her wedding day becomes part of a team of monsters sent in by the U.S. government to defeat an alien mastermind trying to take over Earth.
Susan Murphy / Ginormica (voice)
B.O.B. (voice)
Dr. Cockroach Ph.D. (voice)
Gallaxhar (voice)
The Missing Link (voice)
General W.R. Monger (voice)
Derek Dietl (voice)
President Hathaway (voice)
Wendy Murphy (voice)
Carl Murphy (voice)
Computer (voice)
News Reporter (voice)
Katie (voice)
Private Bullhorn / Helicopter Pilot / Advisor Ortega (voice)
Commander / Advisor Smith (voice) / First Assistant Editor
Secret Service Man #1 / Lieutenant (voice) / Director / Screenplay
Wilson (voice)
Advisor Cole / Army Commander Jones (voice)
Advisor Wedgie (voice)
Technician Jerry (voice)
Director
